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Title: Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy
Authors: Fuloria, Shivkanya
Sekar, Mahendran
Farrah Syazana Khattulanuar
Gan, Siew Hua
Nur Najihah Izzati Mat Rani
Ravi, Subban
Subramaniyan, Vetriselvan
Jeyabalan, Srikanth
Begum, M.Yasmin
Chidambaram, Kumarappan
Sathasivam, Kathirevan V.
Safi, Sher Zaman
Wu, Yuan Seng
Rusdi Nordin
Maziz, Mohammad Nazmul Hasan
Kumarasamy, Vinoth
Lum, Pei Teng
Fuloria, Neeraj Kumar
Keywords: Biosynthesis
Drug discovery
Issue Date: Aug-2022
Publisher: MDPI
Citation: Fuloria, S., Sekar, M., Farrah Syazana Khattulanuar, Gan, S. H., Nur Najihah Izzati Mat Rani, Ravi, S., Subramaniyan, V., Jeyabalan, S., Begum, M. Y., Chidambaram, K., Sathasivam, K. V., Safi, S. Z., Wu, Y. S., Rusdi Nordin, Maziz, M. N. H., Kumarasamy, V., Lum, P. T., & Fuloria, N. K. (2022). Chemistry, Biosynthesis and Pharmacology of Viniferin: Potential Resveratrol-Derived Molecules for New Drug Discovery, Development and Therapy. Molecules, 27(16), 5072.
Abstract: Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial attack, toxins, infections or UV radiation. Different forms of viniferin exist, including alpha-viniferin (α-viniferin), beta-viniferin (β-viniferin), delta-viniferin (δ-viniferin), epsilon-viniferin (ε-viniferin), gamma-viniferin (γ-viniferin), R-viniferin (vitisin A), and R2-viniferin (vitisin B). All of these forms exhibit a range of important biological activities and, therefore, have several possible applications in clinical research and future drug development. In this review, we present a comprehensive literature search on the chemistry and biosynthesis of and the diverse studies conducted on viniferin, especially with regards to its anti-inflammatory, antipsoriasis, antidiabetic, antiplasmodic, anticancer, anti-angiogenic, antioxidant, anti-melanogenic, neurodegenerative effects, antiviral, antimicrobial, antifungal, antidiarrhea, anti-obesity and anthelminthic activities. In addition to highlighting its important chemical and biological activities, coherent and environmentally acceptable methods for establishing vinferin on a large scale are highlighted to allow the development of further research that can help to exploit its properties and develop new phyto-pharmaceuticals. Overall, viniferin and its derivatives have the potential to be the most effective nutritional supplement and supplementary medication, especially as a therapeutic approach. More researchers will be aware of viniferin as a pharmaceutical drug as a consequence of this review, and they will be encouraged to investigate viniferin and its derivatives as pharmaceutical drugs to prevent future health catastrophes caused by a variety of serious illnesses.
ISSN: 14203049
Appears in Collections:Journal Articles

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