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Title: A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin
Authors: Fuloria, Shivkanya
Mehta, Jyoti
Chandel, Aditi
Sekar, Mahendran
Nur Najihah Izzati Mat Rani
Begum, M. Yasmin
Subramaniyan, Vetriselvan
Chidambaram, Kumarappan
Thangavelu, Lakshmi
Rusli Nordin
Wu, Yuan Seng
Sathasivam, Kathiresan V.
Lum, Pei Teng
Meenakshi, Dhanalekshmi Unnikrishnan
Kumarasamy, Vinoth
Azad, Abul Kalam
Fuloria, Neeraj Kumar
Keywords: Curcuma longa
Issue Date: Mar-2022
Publisher: Frontiers Media S.A.
Citation: Fuloria, S., Mehta, J., Chandel, A., Sekar, M., Rani, Nur Najihah Izzati Mat Rani, Begum, M. Y., Subramaniyan, V., Chidambaram, K., Thangavelu, L., Rusli Nordin, Wu, Y. S., Sathasivam, K. V., Lum, P. T., Meenakshi, D. U., Kumarasamy, V., Azad, A. K., & Fuloria, N. K. (2022). A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin. Frontiers in Pharmacology, 13, 820806.
Abstract: Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constituent of C. longa, is well known for its therapeutic potential in numerous disorders. However, there is a lack of literature on the therapeutic potential of C. longa in contrast to curcumin. Hence, the present review aimed to provide in-depth information by highlighting knowledge gaps in traditional and scientific evidence about C. longa in relation to curcumin. The relationship to one another in terms of biological action includes their antioxidant, anti-inflammatory, neuroprotective, anticancer, hepatoprotective, cardioprotective, immunomodulatory, antifertility, antimicrobial, antiallergic, antidermatophytic, and antidepressant properties. Furthermore, in-depth discussion of C. longa on its taxonomic categorization, traditional uses, botanical description, phytochemical ingredients, pharmacology, toxicity, and safety aspects in relation to its major compound curcumin is needed to explore the trends and perspectives for future research. Considering all of the promising evidence to date, there is still a lack of supportive evidence especially from clinical trials on the adjunct use of C. longa and curcumin. This prompts further preclinical and clinical investigations on curcumin.
ISSN: 16639812
Appears in Collections:Journal Articles

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