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http://hdl.handle.net/123456789/29524
Title: | Endosomal Escape of Bioactives Deployed via Nanocarriers: Insights Into the Design of Polymeric Micelles |
Authors: | Butt, Adeel Masood Nabiha Abdullah Nur Najihah Izzati Mat Rani Ahmad, Naveed Mohd Cairul Iqbal Mohd Amin (UniKL RCMP) |
Keywords: | Cytoplasmic delivery Endosomal escape Endosomal targeting pH-sensitive micelles Photochemical internalization Polymeric micelles |
Issue Date: | Jun-2022 |
Publisher: | Springer |
Citation: | Butt, A. M., Nabihah Abdullah, Nur Najihah Izzati Mat Rani, Ahmad, N. & Mohd Cairul Iqbal Mohd Amin. (2022). Endosomal Escape of Bioactives Deployed via Nanocarriers: Insights Into the Design of Polymeric Micelles. Pharmaceutical Research, 39(6), 1047–1064. https://doi.org/10.1007/s11095-022-03296-w |
Abstract: | Cytoplasmic delivery of bioactives requires the use of strategies such as active transport, electroporation, or the use of nanocarriers such as polymeric nanoparticles, liposomes, micelles, and dendrimers. It is essential to deliver bioactive molecules in the cytoplasm to achieve targeted effects by enabling organelle targeting. One of the biggest bottlenecks in the successful cytoplasmic delivery of bioactives through nanocarriers is their sequestration in the endosomes that leads to the degradation of drugs by progressing to lysosomes. In this review, we discussed mechanisms by which nanocarriers are endocytosed, the mechanisms of endosomal escape, and more importantly, the strategies that can be and have been employed for their escape from the endosomes are summarized. Like other nanocarriers, polymeric micelles can be designed for endosomal escape, however, a careful control is needed in their design to balance between the possible toxicity and endosomal escape efficiency. Keeping this in view, polyion complex micelles, and polymers that have the ability to escape the endosome, are fully discussed. Finally, we provided some perspectives for designing the polymeric micelles for efficient cytoplasmic delivery of bioactive agents through endosomal escape. |
URI: | https://ir.unikl.edu.my/jspui/handle/123456789/29524 |
ISSN: | 07248741 |
Appears in Collections: | Journal Articles |
Files in This Item:
File | Description | Size | Format | |
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Endosomal Escape of Bioactives Deployed via Nanocarriers_ Insights Into the Design of Polymeric Micelles _ Pharmaceutical Research (1).pdf | 265.77 kB | Adobe PDF | View/Open |
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