Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/29524
Title: Endosomal Escape of Bioactives Deployed via Nanocarriers: Insights Into the Design of Polymeric Micelles
Authors: Butt, Adeel Masood
Nabiha Abdullah
Nur Najihah Izzati Mat Rani
Ahmad, Naveed
Mohd Cairul Iqbal Mohd Amin
(UniKL RCMP)
Keywords: Cytoplasmic delivery
Endosomal escape
Endosomal targeting
pH-sensitive micelles
Photochemical internalization
Polymeric micelles
Issue Date: Jun-2022
Publisher: Springer
Citation: Butt, A. M., Nabihah Abdullah, Nur Najihah Izzati Mat Rani, Ahmad, N. & Mohd Cairul Iqbal Mohd Amin. (2022). Endosomal Escape of Bioactives Deployed via Nanocarriers: Insights Into the Design of Polymeric Micelles. Pharmaceutical Research, 39(6), 1047–1064. https://doi.org/10.1007/s11095-022-03296-w
Abstract: Cytoplasmic delivery of bioactives requires the use of strategies such as active transport, electroporation, or the use of nanocarriers such as polymeric nanoparticles, liposomes, micelles, and dendrimers. It is essential to deliver bioactive molecules in the cytoplasm to achieve targeted effects by enabling organelle targeting. One of the biggest bottlenecks in the successful cytoplasmic delivery of bioactives through nanocarriers is their sequestration in the endosomes that leads to the degradation of drugs by progressing to lysosomes. In this review, we discussed mechanisms by which nanocarriers are endocytosed, the mechanisms of endosomal escape, and more importantly, the strategies that can be and have been employed for their escape from the endosomes are summarized. Like other nanocarriers, polymeric micelles can be designed for endosomal escape, however, a careful control is needed in their design to balance between the possible toxicity and endosomal escape efficiency. Keeping this in view, polyion complex micelles, and polymers that have the ability to escape the endosome, are fully discussed. Finally, we provided some perspectives for designing the polymeric micelles for efficient cytoplasmic delivery of bioactive agents through endosomal escape.
URI: https://ir.unikl.edu.my/jspui/handle/123456789/29524
ISSN: 07248741
Appears in Collections:Journal Articles



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