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Title: | SYNTHESIS AND MECHANISM STUDY OF NEW BIVALENT β-CARBOLINE DERIVATIVES (Kajian Sintesis dan Mekanisma Derivatif Bivalen β-karbolin Baharu) |
Authors: | Nurul Tasnim Noor Aaisa Karimah Kassim Nur Azzalia Kamaruzaman Mazlin Mohideen (UniKL RCMP) |
Keywords: | Synthesis bivalent β-carboline L-Tryptophan Pictet-Spengler condensation Dimerization |
Issue Date: | Feb-2022 |
Citation: | Nurul Tasnim Noor Aaisa, Karimah Kassim, Nur Azzalia Kamaruzaman, & Mazlin Mohideen. (2022). SYNTHESIS AND MECHANISM STUDY OF NEW BIVALENT β-CARBOLINE DERIVATIVES (Kajian Sintesis dan Mekanisma Derivatif Bivalen β-karbolin Baharu). Malaysian Journal of Analytical Sciences, 26, 1–7. https://mjas.analis.com.my/mjas/v26_n1/pdf/Tasnim_26_1_1.pdf |
Abstract: | This study reports simple and straightforward methods for synthesizing new bivalent β-carboline compounds using L-tryptophan as a starting material with 1,4-dibromobutane as a dimerization linker. The synthetic route began with coupling L-tryptophan with formaldehyde via Pictet-Spengler condensation to afford tetrahydro-β-carboline, T1 as the key intermediate. The reaction proceeded with decarboxylation of T1 using potassium dichromate with acetic acid to afford β-carboline, T2. Subsequent alkylation of T2 using 1,4-dibromobutane as the linker yielded intermediate T3, followed by dimerization to furnish the new bivalent β-carboline, T4. 1H and 13C NMR confirmed all the synthesized compounds. In addition, this study includes the proposed mechanism for the synthesis of a new bivalent β-carboline compound. |
URI: | https://ir.unikl.edu.my/jspui/handle/123456789/29412 |
ISSN: | 13942506 |
Appears in Collections: | Journal Articles |
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SYNTHESIS AND MECHANISM STUDY OF NEW BIVALENT β-CARBOLINE DERIVATIVES (Kajian Sintesis dan Mekanisma Derivatif Bivalen β-karbolin Baharu).pdf | 194.41 kB | Adobe PDF | View/Open |
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