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Title: Chemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy
Authors: Nur Hanisah Mustafa
Sekar, Mahendran
Fuloria, Shivkanya
Begum, Yasmin
Gan, Siew Hua
Nur Najihah Izzati Mat Rani
Ravi, Subban
Chidambaram, Kumarappan
Subramaniyan, Vetriselvan
Sathasivam, Kathiresan V.
Jeyabalan, Srikanth
Uthirapathy, Subasini
Ponnusankar, Sivasankaran
Lum, Pei Teng
Bhalla, Vijay
Fuloria, Neeraj Kumar
Keywords: Sarsasapogenin
Drug development
Issue Date: Mar-2022
Publisher: MDPI
Citation: Nur Hanisah Mustafa, Sekar, M., Fuloria, M. Begum, Y., Gan, S. H. Nur Najihah Izzati Mat Rani, Ravi, S., Chidambaram, K., Subramaniyan, V., Sathasivam, K. V., Jeyabalan, S., Uthirapathy, S., Ponnusankar, S., Lum, P.T., Bhalla, V., & Fuloria, N.K. (2022). Chemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy. Molecules, 27(6), 2032–2032.
Abstract: Sarsasapogenin is a natural steroidal sapogenin molecule obtained mainly from Anemarrhena asphodeloides Bunge. Among the various phytosteroids present, sarsasapogenin has emerged as a promising molecule due to the fact of its diverse pharmacological activities. In this review, the chemistry, biosynthesis and pharmacological potentials of sarsasapogenin are summarised. Between 1996 and the present, the relevant literature regarding sarsasapogenin was obtained from scientific databases including PubMed, ScienceDirect, Scopus, and Google Scholar. Overall, sarsasapogenin is a potent molecule with anti-inflammatory, anticancer, antidiabetic, anti-osteoclastogenic and neuroprotective activities. It is also a potential molecule in the treatment for precocious puberty. This review also discusses the metabolism, pharmacokinetics and possible structural modifications as well as obstacles and opportunities for sarsasapogenin to become a drug molecule in the near future. More comprehensive preclinical studies, clinical trials, drug delivery, formulations of effective doses in pharmacokinetics studies, evaluation of adverse effects and potential synergistic effects with other drugs need to be thoroughly investigated to make sarsasapogenin a potential molecule for future drug development.
ISSN: 14203049
Appears in Collections:Journal Articles

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