Please use this identifier to cite or link to this item: http://ir.unikl.edu.my/jspui/handle/123456789/11693
metadata.conference.dc.title: Synthesis and Evaluation of Analgesic and Anti-inflammatory Activities of Most Active Free Radical Scavenging Derivatives of Mangiferin.
metadata.conference.dc.contributor.*: Sekar, Mahendran,FPHS UniKL RCMP.
S., Badami,FPHS UniKL RCMP.
S., Ravi, FPHS UniKL RCMP.
B. S., Thippeswamy, FPHS UniKL RCMP.
V.P., Veerapur, FPHS UniKL RCMP.
metadata.conference.dc.subject: Mangiferin derivatives
Antioxidant
Analgesic
anti-inflammatory
metadata.conference.dc.date.issued: 16-Jul-2014
metadata.conference.dc.publisher: British Journal of Applied Science & Technology.
metadata.conference.dc.identifier.citation: S. Mahendran, S. Badami, S. Ravi, B. S. Thippeswamy and V. P. Veerapur. (2014). Synthesis and Evaluation of Analgesic and Anti-inflammatory Activities of Most Active Free Radical Scavenging Derivatives of Mangiferin. British Journal of Applied Science & Technology. 4(35). 4959-4973. Doi: 10.9734/BJAST/2014/12745
metadata.conference.dc.description.abstract: In the present study, structural modification of mangiferin was carried out for structure activity relationship studies. One new compound and three known derivatives were prepared from mangiferin. All these compounds were synthesized and purified by standard procedures, identified by using physical and spectral (IR, 1H NMR, 13C NMR and MS) properties. The synthesized mangiferin derivatives were tested for In vitro antioxidant properties. Benzyl and methyl substituted mangiferin showed poor antioxidant activity than mangiferin. However, mangiferin derivatives substituted with acetyl and benzoyl groups were showed potent antioxidant activity than mangiferin in lipid peroxidation, p-NDA, deoxyribose and alkaline DMSO methods. But both the compounds failed to show potent analgesic and anti-inflammatory activities. In all these methods, standard drugs showed better activity than mangiferin and its derivatives.
metadata.conference.dc.identifier.uri: http://localhost/xmlui/handle/123456789/11693
metadata.conference.dc.identifier.issn: 2231-0843
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