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dc.contributor.authorKathirasan, Darsshen Ramana-
dc.contributor.authorSiti Nor ’Izzah Normizan-
dc.contributor.authorNurul Athirah Mohd Salleh-
dc.contributor.authorKhor, Poh Yen-
dc.contributor.author(UniKL RCMP)-
dc.date.accessioned2026-03-09T06:59:20Z-
dc.date.available2026-03-09T06:59:20Z-
dc.date.issued2024-12-
dc.identifier.citationKathirasan DR, Siti Nor ’Izzah Normizan, Nurul Athirah Mohd Salleh, Khor, PY. Recent progress on small molecule TLR4 antagonist against triple-negative breast cancer progression and complications. Bioorganic & Medicinal Chemistry [Internet]. 2024 Nov 14;116:118000. Available from: https://doi.org/10.1016/j.bmc.2024.118000en_US
dc.identifier.issn09680896-
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0968089624004140?via%3Dihub-
dc.identifier.urihttps://ir.unikl.edu.my/jspui/handle/ir.unikl.edu.my/33969-
dc.description.abstractToll-like receptor 4 (TLR4) plays a vital role in the innate immune response, but its overactivation has been associated with several diseases, such as aggressive progression of triple-negative breast cancer (TNBC). As a result, inhibiting TLR4 has emerged as a potential therapeutic strategy for this challenging breast cancer subtype. This review summarizes recent advancements in the development of small-molecule TLR4 antagonists to suppress TNBC growth, metastasis, and chemotherapy resistance. We also examine their potential in managing cancer-related complications and propose future directions for their application in TNBC therapy.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.subjectAngiogenesisen_US
dc.subjectBreast canceren_US
dc.subjectComplicationen_US
dc.subjectMetastasesen_US
dc.subjectMyeloid differentiation factor 2en_US
dc.titleRecent progress on small molecule TLR4 antagonist against triple-negative breast cancer progression and complicationsen_US
dc.typeArticleen_US
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