Role of Antimicrobial Peptides as Potential Arsenal Against SARS-CoV-2 and Other Pathogens

Abstract

Antimicrobial peptides (AMPs) represent a diverse group of short peptides that are widely distributed across various organisms and serve as essential defense agents. Their crucial role in combating the escalating threat of antimicrobial resistance has heightened their significance in global research. This comprehensive review discusses the structures, characteristics, classifications, and mechanisms of action of AMPs, outlining their diverse biological functions. AMPs exhibit notable potential in antimicrobial, antiviral, antifungal, and antiparasitic activities, and have significant applications in immune response orchestration and anticancer therapies. Notably, this review highlights the emerging role of AMPs in combating the SARS-CoV-2, including their potential as a promising therapeutic strategy. Additionally, the potential utilization of AMPs in diagnostics, along with their prospects in the development of novel therapeutics, is thoroughly examined, underlining their significant clinical implications.