Please use this identifier to cite or link to this item: http://ir.unikl.edu.my/jspui/handle/123456789/9392
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dc.contributor.authorAl-Jasabi, S.-
dc.contributor.authorAbdullah, M.S.-
dc.contributor.authorUniKL RCMP, Faculty of Pharmacy and Health Sciences-
dc.date.accessioned2015-03-02T03:09:05Z-
dc.date.available2015-03-02T03:09:05Z-
dc.date.issued2013-
dc.identifier.citationThe Role of Antioxidant Hesperidin in the Attenuation of Lung Cancer Caused by Benzo[a]pyrene in Balb/c Mice.World Applied Sciences Journal,22 (8), 1106-1110. Retrieved from citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.388.5376...en_US
dc.identifier.issn1818-4952-
dc.identifier.urihttp://localhost/xmlui/handle/123456789/9392-
dc.description.abstractIt was postulated that chemoprevention is one of the most promising and realistic approaches in the prevention of cancer. Hesperidin (HDN) is one such naturally occurring flavonoid widely found in citrus fruits. The aim of the present study is to divulge the chemopreventive nature of HDN during benzo[a]pyrene (b[a]p) induced lung cancer in BALB/c mice. Administration of b[a]p (60 mg/kg body weight) to mice resulted in increased lipid peroxidation (LPO), lung specific tumor marker carcinoembryonic antigen (CEA) and serum marker enzymes aryl hydrocarbon hydroxylase (AHH), alanine transaminase (ALT), with concomitant decrease in the levels of tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione. HDN supplementation (25 mg/kg body weight) significantly attenuated these alterations thereby showing potent anticancer effect in lung cancer. Overall, these findings substantiate the chemoprotective potential of HDN against chemically-induced lung cancer in BALB/c mice.en_US
dc.language.isoenen_US
dc.publisherWorld Applied Sciences Journalen_US
dc.subjectHesperidinen_US
dc.subjectAntioxidanten_US
dc.subjectBenzo[A]Pyrineen_US
dc.subjectFlavonoidsen_US
dc.subjectLung Canceren_US
dc.titleThe Role of Antioxidant Hesperidin in the Attenuation of Lung Cancer Caused by Benzo[a]pyrene in Balb/c Miceen_US
dc.typeArticleen_US
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