Molecular engineering of a theranostic molecule that detects Aβ plaques, inhibits Iowa and Dutch mutation Aβ self-aggregation and promotes lysosomal biogenesis for Alzheimer's disease

Extracellular clustering of amyloid-β (Aβ) and an impaired autophagy lysosomal pathway (ALP) are the hallmark features in the early stages of incurable Alzheimer's disease (AD). There is a pressing need to find or develop new small molecules for diagnostics and therapeutics for the&...

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Knowledge and attitudes towards and prevalence of overweight and obesity among undergraduate students at Universiti Kuala Lumpur Royal College of Medicine: A crosssectional study

Introduction: Overweight and obesity pose significant health risks, affecting social and economic well-being and potentially hindering mental health and learning outcomes. This study investigated the knowledge, attitudes, and prevalence of overweight and obesity among undergraduate students&...

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Pharmacist-led interventions in addressing improper disposal practices of unused and expired household medication: A systematic review

Background: Improper household medication disposal practices are a source of significant threat to environmental safety and public health. Pharmacists play a crucial role in mitigating these risks by educating the public about proper medication disposal. Evidence regarding the effectiveness of ef...

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Nanoparticulate BDNF as A Potential Antidepressant via Neuroendocrine Mechanisms in Experimental Model of Depression

Objective: To study the effect of a nanoparticulate brain-derived neurotrophic factor with surfactant (BDNF) on the modeled depression not associated with stress in mice. Methods: Thirty-six C57BL/6 mice weighing 20-25 g were included in the study with reserpine-induced depression. The anima...

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In vitro Inhibitory effects of Polyherbal Formulation on Biofilm-forming bacteria in Chronic wounds

Biofilm is a complex microbial community highly resistant to antimicrobials. The formation of biofilms in biotic and abiotic surfaces is associated with high rates of morbidity and mortality in hospitalized patients. The aim of the present study was to develop a polyherbal formulation&#...

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Intraoperative Rare Complication of Excision of a Large Loop Transformation Zone

The case study discussed patient oriented quality care can enhance patient safety and increase the competency of healthcare professionals, even when they follow standard operating procedures and deal with unforeseen complications in performing LLETZ. This case report aims at validating the q...

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In vitro 3D skin culture and its sustainability in toxicology: a narrative review

In current toxicological research, 2D cell cultures and animal models are well- accepted and commonly employed methods. However, these approaches have many drawbacks and are distant from the actual environment in human. To embrace this, great efforts have been made to provide alternativ...

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Impact of PNF and MET technique on hamstring flexibility among university students with hamstring tightness

Background. Hamstring tightness affects pelvic posture, contributing to symptoms such as low back discomfort and improper lumbar-pelvic area motions. The purpose of this study is to determine the immediate effectiveness of both Proprioceptive Neuromuscular Facilitation (PNF) and Muscle Energy Techniqu...

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Synthesis and characterization of 4-nitro benzaldehyde with ZnO-based nanoparticles for biomedical applications

Globally, cancer is the leading cause of death and morbidity, and skin cancer is the most common cancer diagnosis. Skin problems can be treated with nanoparticles (NPs), particularly with zinc oxide (ZnO) NPs, which have antioxidant, antibacterial, anti-inflammatory, and anticancer properties.&#x...

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Karanjin: a potential furanoflavonoid for neuroprotection

Phytochemicals are widely known for the pharmacological effects in treating various human conditions and in recent years, new compounds are being discovered with substantial health benefits. Karanjin is a furanoflavonoid mainly isolated from Millettia pinnata L., emerging in the field of pha...

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