In vitro 3D skin culture and its sustainability in toxicology: a narrative review

In current toxicological research, 2D cell cultures and animal models are well- accepted and commonly employed methods. However, these approaches have many drawbacks and are distant from the actual environment in human. To embrace this, great efforts have been made to provide alternativ...

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Impact of PNF and MET technique on hamstring flexibility among university students with hamstring tightness

Background. Hamstring tightness affects pelvic posture, contributing to symptoms such as low back discomfort and improper lumbar-pelvic area motions. The purpose of this study is to determine the immediate effectiveness of both Proprioceptive Neuromuscular Facilitation (PNF) and Muscle Energy Techniqu...

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Synthesis and characterization of 4-nitro benzaldehyde with ZnO-based nanoparticles for biomedical applications

Globally, cancer is the leading cause of death and morbidity, and skin cancer is the most common cancer diagnosis. Skin problems can be treated with nanoparticles (NPs), particularly with zinc oxide (ZnO) NPs, which have antioxidant, antibacterial, anti-inflammatory, and anticancer properties.&#x...

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Karanjin: a potential furanoflavonoid for neuroprotection

Phytochemicals are widely known for the pharmacological effects in treating various human conditions and in recent years, new compounds are being discovered with substantial health benefits. Karanjin is a furanoflavonoid mainly isolated from Millettia pinnata L., emerging in the field of pha...

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Genomic surveillance of omicron B.1.1.529 SARS-CoV-2 and its variants between December 2021 and March 2023 in Tamil Nadu, India—A state-wide prospective longitudinal study

A state-wide prospective longitudinal investigation of the genomic surveillance of the omicron B.1.1.529 SARS-CoV-2 variant and its sublineages in Tamil Nadu, India, was conducted between December 2021 and March 2023. The study aimed to elucidate their mutational patterns and their genetic i...

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Chemistry, Pharmacology and Therapeutic Potential of Decursin: A Promising Natural Lead for New Drug Discovery and Development

Decursin is a pyranocoumarin compounds which are rare secondary metabolic plant products, isolated from the roots of Angelica gigas (A. gigas). The native Korean species Angelica gigas Nakai (AGN) is widely used as a remedy for a variety of medical conditions including hematopoiesis,&#x...

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Bioengineered silver nanoparticles induced apoptosis through upregulation of caspase 3 and caspase 8 proteins in breast adenocarcinoma MDA-MB-231 cells and impede angiogenesis

In recent years, a lot of research has been done on silver nanoparticles (SNP) due to their numerous applications in the biomedical, pharmaceutical, and drug delivery industries. In this present study SNP were green synthesized using Melicope lunu-ankenda (M. lunu-ankenda) leaf extract. ...

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Antiparasitic, Antibacterial and Antifungal Properties of Essential Oils Obtained from Medicinal Plants Available in the Southeast Asian Region

According to several reports, the annual deaths recorded worldwide due to infection caused by resistant bacteria, fungi and parasite were > 0.75-, > 1.5- and > 9.0-million deaths, respectively, which seems to indicate their significant impact on human health. These could be att...

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Antioxidant and Antibacterial Activities of Coriander (Coriander sativum L.) Seeds Essential Oil

Natural products offer a wide range of possibilities for the development of new remedies. Coriander (Coriandrum sativum L.) seeds have been reported to contain numerous biological activities. This study aims to determine the antioxidant and antibacterial activities of coriander seeds essential&#x...

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Recent progress on small molecule TLR4 antagonist against triple-negative breast cancer progression and complications

Toll-like receptor 4 (TLR4) plays a vital role in the innate immune response, but its overactivation has been associated with several diseases, such as aggressive progression of triple-negative breast cancer (TNBC). As a result, inhibiting TLR4 has emerged as a potential therapeutic str...

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