Please use this identifier to cite or link to this item:
Title: Promising nutritional fruits against cardiovascular diseases: An overview of experimental evidence and understanding their mechanisms of action
Authors: Zulaikha Azwa Zuraini
Sekar, Mahendran
Wu, Yuan Seng 
Gan, Siew Hua 
Bonam, Srinivasa Reddy
Nur Najihah Izzati Mat Rani
Begum, Yasmin
Lum, Pei Teng
Subramaniyan, Vetriselvan
Fuloria, Neeraj Kumar
Fuloria, Shivkanya
Keywords: Antioxidant
Cardiovascular diseases
Heart disease
Nutritional fruits
Issue Date: Nov-2021
Publisher: Dove Medical Press Ltd
Citation: Zulaikha Azwa Zuraini, Sekar, M., Wu, Y. S., Gan, S. H., Bonam, S. R., Nur Najihah Izzati Mat Rani, Begum, M. Y., Lum, P. T., Subramaniyan, V., Fuloria, N. K., & Fuloria, S. (2021). Promising Nutritional Fruits Against Cardiovascular Diseases: An Overview of Experimental Evidence and Understanding Their Mechanisms of Action. Vascular Health and Risk Management, Volume 17, 739–769.
Abstract: Cardiovascular diseases (CVDs) are one of the leading causes of morbidity and mortality in both developed and developing countries, affecting millions of individuals each year. Despite the fact that successful therapeutic drugs for the management and treatment of CVDs are available on the market, nutritional fruits appear to offer the greatest benefits to the heart and have been proved to alleviate CVDs. Experimental studies have also demonstrated that nutritional fruits have potential protective effects against CVDs. The aim of the review was to provide a comprehensive summary of scientific evidence on the effect of 10 of the most commonly available nutritional fruits reported against CVDs and describe the associated mechanisms of action. Relevant literatures were searched and collected from several scientific databases including PubMed, ScienceDirect, Google Scholar and Scopus. In the context of CVDs, 10 commonly consumed nutritious fruits including apple, avocado, grapes, mango, orange, kiwi, pomegranate, papaya, pineapple, and watermelon were analysed and addressed. The cardioprotective mechanisms of the 10 nutritional fruits were also compiled and high-lighted. Overall, the present review found that the nutritious fruits and their constituents have significant benefits for the management and treatment of CVDs such as myocardial infarction, hypertension, peripheral artery disease, coronary artery disease, cardiomyopathies, dyslipide-mias, ischemic stroke, aortic aneurysm, atherosclerosis, cardiac hypertrophy and heart failure, diabetic cardiovascular complications, drug-induced cardiotoxicity and cardiomyopathy. Among the 10 nutritional fruits, pomegranate and grapes have been well explored, and the mechanisms of action are well documented against CVDs. All of the nutritional fruits men-tioned are edible and readily accessible on the market. Consuming these fruits, which may contain varying amounts of active constituents depending on the food source and season, the development of nutritious fruits-based health supplements would be more realistic for con-sistent CVD protection.
ISSN: 11766344
Appears in Collections:Journal Articles

Files in This Item:
File Description SizeFormat 
Promising Nutritional Fruits Against Cardiovascular.pdf16.49 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.