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Title: Mangifera indica (Mango): A promising medicinal plant for breast cancer therapy and understanding its potential mechanisms of action
Authors: Yap, Kah Min
Sekar, Mahendran
Seow, Lay Jing
Gan, Siew Hua
Bonam, Srinivasa Reddy
Nur Najihah Izzati Mat Rani
Lum, Pei Teng
Subramaniyan, Vetriselvan
Wu, Yuan Seng
Fuloria, Neeraj Kumar
Fuloria, Shivkanya
Keywords: Mango
Mangifera indica
Breast cancer
Molecular mechanism
Natural products
Women’s health
Issue Date: 2021
Publisher: Dove Medical Press Ltd
Citation: Yap, K. M., Sekar, M., Seow, L. J., Gan, S. H., Bonam, S. R., Nur Najihah Izzati Mat Rani, Lum, P. T., Subramaniyan, V., Wu, Y. S., Fuloria, N. K., & Fuloria, S. (2021). Mangifera indica (Mango): A Promising Medicinal Plant for Breast Cancer Therapy and Understanding Its Potential Mechanisms of Action. Breast Cancer: Targets and Therapy, 13, 471–503.
Abstract: Globally, breast cancer is the most common cancer type and is one of the most significant causes of deaths in women. To date, multiple clinical interventions have been applied, including surgical resection, radiotherapy, endocrine therapy, targeted therapy and chemotherapy. However, 1) the lack of therapeutic options for metastatic breast cancer, 2) resistance to drug therapy and 3) the lack of more selective therapy for triple-negative breast cancer are some of the major challenges in tackling breast cancer. Given the safe nature of natural products, numerous studies have focused on their anti-cancer potentials. Mangifera indica, commonly known as mango, represents one of the most extensively investigated natural sources. In this review, we provide a comprehensive overview of M. indica extracts (bark, kernel, leaves, peel and pulp) and phytochemicals (mangiferin, norathyriol, gallotannins, gallic acid, pyrogallol, methyl gallate and quercetin) reported for in vitro and in vivo anti-breast cancer activities and their underlying mechanisms based on relevant literature from several scientific databases, including PubMed, Scopus and Google Scholar till date. Overall, the in vitro findings suggest that M. indica extracts and/or phytochemicals inhibit breast cancer cell growth, proliferation, migration and invasion as well as trigger apoptosis and cell cycle arrest. In vivo results demonstrated that there was a reduction in breast tumor xenograft growth. Several potential mechanisms underlying the anti-breast cancer activities have been reported, which include modulation of oxidative status, receptors, signalling pathways, miRNA expression, enzymes and cell cycle regulators. To further explore this medicinal plant against breast cancer, future research directions are addressed. The outcomes of the review revealed that M. indica extracts and their phytochemicals may have potential benefits in the management of breast cancer in women. However, to validate its utility in the creation of innovative and potent therapeutic agents to treat breast cancer, more dedicated research, especially clinical studies are needed to explore the anti-breast cancer potentials of M. indica extracts and their phytochemicals
ISSN: 11791314
Appears in Collections:Journal Articles

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