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http://hdl.handle.net/123456789/26058
Title: | Comprehensive review of methodology to detect reactive oxygen species (Ros) in mammalian species and establish its relationship with antioxidants and cancer |
Authors: | Shivkanya, Fuloria Vetriselvan, Subramaniyan Sundram, Karupiah Usha, Kumari Kathiresan, Sathasivam Dhanalekshmi Unnikrishnan, Meenakshi Yuan Seng, Wu Mahendran, Sekar Nitin, Chitranshi Rishabha, Malviya Kalvatala, Sudhakar Sakshi, Bajaj Neeraj Kumar, Fuloria (UniKL RCMP) |
Keywords: | Reactive Oxygen Species Antioxidants Detection Methods Harmful Beneficial Effects |
Issue Date: | Jan-2021 |
Publisher: | MDPI |
Citation: | Fuloria, S., Subramaniyan, V., Karupiah, S., Kumari, U., Sathasivam, K., Meenakshi, D. U., Wu, Y. S., Sekar, M., Chitranshi, N., Malviya, R., Sudhakar, K., Bajaj, S., & Fuloria, N. K. (2021). Comprehensive Review of Methodology to Detect Reactive Oxygen Species (ROS) in Mammalian Species and Establish Its Relationship with Antioxidants and Cancer. Antioxidants, 10(1). https://doi.org/10.3390/antiox10010128 |
Abstract: | Evidence suggests that reactive oxygen species (ROS) mediate tissue homeostasis, cellular signaling, differentiation, and survival. ROS and antioxidants exert both beneficial and harmful effects on cancer. ROS at different concentrations exhibit different functions. This creates necessity to understand the relation between ROS, antioxidants, and cancer, and methods for detection of ROS. This review highlights various sources and types of ROS, their tumorigenic and tumor prevention effects; types of antioxidants, their tumorigenic and tumor prevention effects; and abnormal ROS detoxification in cancer; and methods to measure ROS. We conclude that improving genetic screening methods and bringing higher clarity in determination of enzymatic pathways and scale-up in cancer models profiling, using omics technology, would support in-depth understanding of antioxidant pathways and ROS complexities. Although numerous methods for ROS detection are developing very rapidly, yet further modifications are required to minimize the limitations associated with currently available methods. |
URI: | https://doi.org/10.3390/antiox10010128 http://hdl.handle.net/123456789/26058 |
ISSN: | 20763921 |
Appears in Collections: | Journal Articles |
Files in This Item:
File | Description | Size | Format | |
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Comprehensive Review of Methodology to Detect Reactive Oxygen Species (ROS) in Mammalian Species and Establish Its Relationship with Antioxidants and Cancer.pdf | 1.4 MB | Adobe PDF | View/Open |
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