Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/26058
Title: Comprehensive review of methodology to detect reactive oxygen species (Ros) in mammalian species and establish its relationship with antioxidants and cancer
Authors: Shivkanya, Fuloria
Vetriselvan, Subramaniyan
Sundram, Karupiah
Usha, Kumari
Kathiresan, Sathasivam
Dhanalekshmi Unnikrishnan, Meenakshi
Yuan Seng, Wu
Mahendran, Sekar
Nitin, Chitranshi
Rishabha, Malviya
Kalvatala, Sudhakar
Sakshi, Bajaj
Neeraj Kumar, Fuloria
(UniKL RCMP)
Keywords: Reactive Oxygen Species
Antioxidants
Detection Methods
Harmful
Beneficial Effects
Issue Date: Jan-2021
Publisher: MDPI
Citation: Fuloria, S., Subramaniyan, V., Karupiah, S., Kumari, U., Sathasivam, K., Meenakshi, D. U., Wu, Y. S., Sekar, M., Chitranshi, N., Malviya, R., Sudhakar, K., Bajaj, S., & Fuloria, N. K. (2021). Comprehensive Review of Methodology to Detect Reactive Oxygen Species (ROS) in Mammalian Species and Establish Its Relationship with Antioxidants and Cancer. Antioxidants, 10(1). https://doi.org/10.3390/antiox10010128
Abstract: Evidence suggests that reactive oxygen species (ROS) mediate tissue homeostasis, cellular signaling, differentiation, and survival. ROS and antioxidants exert both beneficial and harmful effects on cancer. ROS at different concentrations exhibit different functions. This creates necessity to understand the relation between ROS, antioxidants, and cancer, and methods for detection of ROS. This review highlights various sources and types of ROS, their tumorigenic and tumor prevention effects; types of antioxidants, their tumorigenic and tumor prevention effects; and abnormal ROS detoxification in cancer; and methods to measure ROS. We conclude that improving genetic screening methods and bringing higher clarity in determination of enzymatic pathways and scale-up in cancer models profiling, using omics technology, would support in-depth understanding of antioxidant pathways and ROS complexities. Although numerous methods for ROS detection are developing very rapidly, yet further modifications are required to minimize the limitations associated with currently available methods.
URI: https://doi.org/10.3390/antiox10010128
http://hdl.handle.net/123456789/26058
ISSN: 20763921
Appears in Collections:Journal Articles



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.