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Title: Lutein: A Comprehensive Review on its Chemical, Biological Activities and Therapeutic Potentials
Authors: Nurul Iman Nurul Fuad
Sekar, Mahendran
Gan, Siew Hua
Lum, Pei Teng
Vaijanathappa, Jaishree
Ravi, Subban
Keywords: Antioxidant
Inflammatory cytokines
Molecular targets
Transcription factors
Issue Date: Nov-2020
Publisher: EManuscript Technologies
Citation: Nurul Iman Nurul Fuad, Sekar, M., Gan, S. H., Lum, P. T., Vaijanathappa, J., & Ravi, S. (2020). Lutein: A Comprehensive Review on its Chemical, Biological Activities and Therapeutic Potentials. Pharmacognosy Journal, 12(6s), 1769–1778.
Abstract: Background: Lutein is a naturally occurring carotenoid found in high amounts in flowers, grains, fruits and green vegetables with green leaves include spinach, kale and carrots. The market for lutein encompasses pharmaceutical, dietary supplement, food, animal and fish feed industries. Objective: The present review aimed to provide an updated and comprehensive analysis of lutein, including its chemistry, biological properties and therapeutic potentials. Methods: Relevant literatures were collected from several scientific databases, include Google Scholar, Pubmed and ScienceDirect between 2000 to till date. Following a detailed inclusion and exclusion screening process, the information obtained was summarized. Results: Information on the sources, chemistry and biological properties including antioxidant, anti-arthrisits, anti-inflammatory, hepatoprotective, cardioprotective, anti-cataract, antidiabetic, anticancer and bone remodelling activities, as well as food industry processing for lutein were tabled. Lutein can be considered powerful antioxidants along with multifaceted molecular targets, such as NF-ҡB, PI3K/Akt, Nrf-2, HO-1 and SIRT-1 signaling pathways in various pathological conditions. Conclusion: The present review observe the chemical, pharmacological properties, in addition to the therapeutic potentials of lutein. It is hoped that the information can provide a good reference to aid in the development and utilization of lutein in phytopharmaceuticals and food industries.
ISSN: 09753575
Appears in Collections:Journal Articles

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