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http://hdl.handle.net/123456789/25070
Title: | Anti-diabetic activity of diphenhydramine in diabetic rats |
Authors: | Chayng, Pang Jyh Ambia, Kaswandi Md Ain, Nurul Noah, Rahim Md |
Keywords: | Diabetic rat Diphenhydramine Hydrochloride Glibenclamide Streptozotocin |
Issue Date: | 22-Sep-2020 |
Publisher: | J. K. Welfare and Pharmascope Foundation |
Citation: | Pang Jyh Chayng, Nurul Ain, Kaswandi Md Ambia, & Rahim Md Noah. (2020). Anti-diabetic activity of diphenhydramine in diabetic rats. International Journal of Research in Pharmaceutical Sciences, 11(4), 5067-5070. https://doi.org/10.26452/ijrps.v11i4.3102 |
Abstract: | The purpose of this project is to study the anti-diabetic effect of diphenhy-dramine on a diabetic rat model. A total of Twenty male Sprague Dawley rats were used and it randomly distributed into four groups which are Group I: Glibenclamide, Group II: negative control, Group III: Diphenhydramine and Group IV: Diphenhydramine and Glibenclamide. In vivo diabetic model were induced with Streptozocin via intraperitoneal injection at the dosage of 65mg/kg. Bodyweight and FBG (Fasting Blood Glucose) level of diabetic rats were assessed every three days. Blood was collected via cardiac puncture at day 21 after the induction of treatment. Insulin level of the rats was assessed with the Mercodia Rat Insulin ELISA kit. FBG level of group I (12.16 ±3.96, p<0.05) and group IV (11.34 ±3.67, p<0.05) were significantly decreased. Meanwhile, the bodyweight for all rats did not show any significant increase. However, the insulin level was escalated in group IV (0.74+0.25, p<0.05) sig-nificantly. The present study shows that the diphenhydramine and the combination of diphenhydramine and glibenclamide lowered blood glucose level and enhanced insulin secretion. © 2020 International Journal of Research in Pharmaceutical Sciences. All rights reserved. |
Description: | The article indexes by scopus |
URI: | http://hdl.handle.net/123456789/25070 |
ISSN: | 9757538 |
Appears in Collections: | Journal Articles |
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