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http://hdl.handle.net/123456789/29818
Title: | Effects of Phomopsidione on the Viability, Virulence, and Metabolites Profile of Methicillin-Resistant Staphylococcus aureus (MRSA) |
Authors: | Chean-Ring Leong Woei-Yenn Tong (UNIKL MICET) |
Issue Date: | 17-Apr-2024 |
Abstract: | Methicillin-resistant Staphylococcus aureus (MRSA) infections have become one of the most threatening multidrug-resistant pathogens. Thus, an ongoing search for anti-MRSA compounds remains an urgent need to effectively treating MRSA infections. Phomopsidione, a novel antibiotic isolated from Diaporthe fraxini, has previously demonstrated potent anti-candidal activity. The present study aimed to investigate the effects of phomopsidione on the viability, virulence, and metabolites profile of MRSA. MRSA was sensitive to phomopsidione in a concentration-dependent manner. Phomopsidione exhibited minimum inhibitory concentration and minimum bactericidal concentration of 62.5 and 500.00 µg/mL against MRSA on broth microdilution assay. The compound showed significant reduction in virulence factors production including extracellular polymeric substances quantification, catalase, and lipase. An untargeted metabolomics analysis using liquid chromatography-high resolution mass spectrometry revealed a significant difference in the metabolites profile of MRSA with 13 putatively identified discriminant metabolites. The present study suggested the potential of phomopsidione as a promising anti-MRSA agent. |
Description: | This article is index by Scopus |
URI: | http://hdl.handle.net/123456789/29818 |
Appears in Collections: | Journal Articles |
Files in This Item:
File | Description | Size | Format | |
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Scopus March 2024_Part5.pdf | 140.84 kB | Adobe PDF | View/Open |
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