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DC Field | Value | Language |
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dc.contributor.author | Rameshkumar, Marimuthu Ragavan | - |
dc.contributor.author | Arunagirinathan, Narasingam | - |
dc.contributor.author | Senthamilselvan, Balasubramanian | - |
dc.contributor.author | Swathirajan, Chinnambedu Ravichandran | - |
dc.contributor.author | Solomon, Sunil Suhas | - |
dc.contributor.author | Vignesh, Ramachandran | - |
dc.contributor.author | Balakrishnan, Pachamuthu | - |
dc.contributor.author | Aljowaie, Reem M. | - |
dc.contributor.author | Almaary, Khalid S. | - |
dc.contributor.author | Chen, Tse-Wei | - |
dc.contributor.author | (UniKL RCMP) | - |
dc.date.accessioned | 2022-12-02T02:12:34Z | - |
dc.date.available | 2022-12-02T02:12:34Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.citation | Rameshkumar, M. R., Arunagirinathan, N., Senthamilselvan, B., Swathirajan, C. R., Solomon, S. S., Vignesh, R., Balakrishnan, P., Aljowaie, R. M., Almaary, K. S., & Chen, T.-W. (2021). Occurrence of extended-spectrum β-lactamase, AmpC, and carbapenemase-producing genes in gram-negative bacterial isolates from human immunodeficiency virus infected patients. Journal of Infection and Public Health, 14(12), 1881–1886. https://doi.org/10.1016/j.jiph.2021.11.008 | en_US |
dc.identifier.issn | 18760341 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1876034121003713?via%3Dihub | - |
dc.identifier.uri | http://hdl.handle.net/123456789/26396 | - |
dc.description.abstract | Background: Progressive decline of immune response in HIV patients makes them susceptible to frequent bacterial infections. High usage of antibiotics influences the emergence of multidrug-resistant bacteria and worsens the clinical outcomes. In this study, the occurrence of drug-resistant genes in Gram-negative bacterial isolates from HIV patients in South India was analyzed. Methods: A total of 173 Gram-negative bacterial (GNB) isolates from HIV patients were screened for antibiotic susceptibility profile using the Kirby-Bauer diskdiffusion method. Positivity of drug-resistant genes was analyzed using polymerase chain reaction method. Results: In this study, 72.8% of bacterial isolates were obtained from urine specimens, and Escherichia coli (47.4%) was the predominantly isolated bacterium. Overall, 87.3% and 83.2% of GNB were resistant to 3rd generation cephalosporin antibiotics such as cefotaxime and ceftazidime, respectively, 56.6% were resistant to cephamycin (cefoxitin) and 43% to carbapenem (imipenem) antibiotics. Extended-spectrum β-lactamases (ESBL) production was noted among 79.5% of GNB isolates, followed by AmpC (57.1%) and Metallo β-lactamases (37.3%). Molecular analysis revealed that ESBL genes such as blaTEM (94.1%), blaCTX-M (89.2%), and blaSHV (24.2%) were detected at higher levels among GNB isolates. Carbapenemase-producing genes such as blaOXA-48 (20%), blaOXA-23 (2.6%), and both blaOXA-23 and blaOXA-51 like genes (2.6%) and AmpC producing genes such as blaCIT (26.7%), blaDHA (3.6%), and blaACC (1.8%) were detected at low-level. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Ltd | en_US |
dc.subject | blaCTX-M | en_US |
dc.subject | Extended-spectrum β-lactamases | en_US |
dc.subject | HIV patients | en_US |
dc.subject | Klebsiella pneumoniae | en_US |
dc.subject | Multidrug-resistant | en_US |
dc.title | Occurrence of extended-spectrum β-lactamase, AmpC, and carbapenemase-producing genes in gram-negative bacterial isolates from human immunodeficiency virus infected patients | en_US |
dc.type | Article | en_US |
Appears in Collections: | Journal Articles |
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