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http://hdl.handle.net/123456789/26091
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DC Field | Value | Language |
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dc.contributor.author | Ahsan, Nagib | - |
dc.contributor.author | Rao, R. Shyama Prasad | - |
dc.contributor.author | Wilson, Rashaun S. | - |
dc.contributor.author | Punyamurtula, Ujwal | - |
dc.contributor.author | Salvato, Fernanda | - |
dc.contributor.author | Petersen, Max | - |
dc.contributor.author | Ahmed, Mohammad Kabir | - |
dc.contributor.author | Abid, M. Ruhul | - |
dc.contributor.author | Verburgt, Jacob C. | - |
dc.contributor.author | Kihara, Daisuke | - |
dc.contributor.author | Yang, Zhibo | - |
dc.contributor.author | Fornelli, Luca | - |
dc.contributor.author | Foster, Steven B. | - |
dc.contributor.author | Ramratnam, Bharat | - |
dc.contributor.author | (UniKL RCMP) | - |
dc.date.accessioned | 2022-10-28T04:15:40Z | - |
dc.date.available | 2022-10-28T04:15:40Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.citation | Ahsan, N., Rao, R. S. P., Wilson, R. S., Punyamurtula, U., Salvato, F., Petersen, M., Ahmed, M. K., Abid, M. R., Verburgt, J. C., Kihara, D., Yang, Z., Fornelli, L., Foster, S. B., & Ramratnam, B. (2021). Mass spectrometry‐based proteomic platforms for better understanding of SARS‐CoV‐2 induced pathogenesis and potential diagnostic approaches. Proteomics, 21(10), 2000279. https://doi.org/10.1002/pmic.202000279 | en_US |
dc.identifier.issn | 16159853 | - |
dc.identifier.uri | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/pmic.202000279 | - |
dc.identifier.uri | http://hdl.handle.net/123456789/26091 | - |
dc.description.abstract | While protein–protein interaction is the first step of the SARS-CoV-2 infection, recent comparative proteomic profiling enabled the identification of over 11,000 protein dynamics, thus providing a comprehensive reflection of the molecular mechanisms underlying the cellular system in response to viral infection. Here we summarize and rationalize the results obtained by various mass spectrometry (MS)-based proteomic approaches applied to the functional characterization of proteins and pathways associated with SARS-CoV-2-mediated infections in humans. Comparative analysis of cell-lines versus tissue samples indicates that our knowledge in proteome profile alternation in response to SARS-CoV-2 infection is still incomplete and the tissue-specific response to SARS-CoV-2 infection can probably not be recapitulated efficiently by in vitro experiments. However, regardless of the viral infection period, sample types, and experimental strategies, a thorough cross-comparison of the recently published proteome, phosphoproteome, and interactome datasets led to the identification of a common set of proteins and kinases associated with PI3K-Akt, EGFR, MAPK, Rap1, and AMPK signaling pathways. Ephrin receptor A2 (EPHA2) was identified by 11 studies including all proteomic platforms, suggesting it as a potential future target for SARS-CoV-2 infection mechanisms and the development of new therapeutic strategies. We further discuss the potentials of future proteomics strategies for identifying prognostic SARS-CoV-2 responsive age-, gender-dependent, tissue-specific protein targets | en_US |
dc.language.iso | en | en_US |
dc.publisher | John Wiley and Sons Inc | en_US |
dc.subject | Biomarkers | en_US |
dc.subject | Comparative proteomics | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Kinase-substrate signaling | en_US |
dc.subject | Post-translational modifications | en_US |
dc.subject | Targeted proteomic | en_US |
dc.subject | Stop-down proteomics | en_US |
dc.title | Mass spectrometry-based proteomic platforms for better understanding of SARS-CoV-2 induced pathogenesis and potential diagnostic approaches | en_US |
dc.type | Article | en_US |
Appears in Collections: | Journal Articles |
Files in This Item:
File | Description | Size | Format | |
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Mass spectrometry‐based proteomic platforms for better understanding of SARS‐CoV‐2 induced.pdf | 3.06 MB | Adobe PDF | View/Open |
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