Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/26082
Title: | Mesenchymal stem cell-derived extracellular vesicles: Regenerative potential and challenges |
Authors: | Fuloria, Shivkanya Subramaniyan, Vetriselvan Dahiya, Rajiv Dahiya, Sunita Sudhakar, Kalvatala Kumari, Usha Sathasivam, Kathiresan Meenakshi, Dhanalekshmi Unnikrishnan Wu, Yuan Seng Sekar, Mahendran Malviya, Rishabha Singh, Amit Fuloria, Neeraj Kumar (UniKL RCMP) |
Keywords: | Extracellular vesicles Regenerative potential Therapeutics Cell injury Stem cells |
Issue Date: | Mar-2021 |
Publisher: | MDPI AG |
Citation: | Fuloria, S., Subramaniyan, V., Dahiya, R., Dahiya, S., Sudhakar, K., Kumari, U., Sathasivam, K., Meenakshi, D. U., Wu, Y. S., Sekar, M., Malviya, R., Singh, A., & Fuloria, N. K. (2021). Mesenchymal Stem Cell-Derived Extracellular Vesicles: Regenerative Potential and Challenges. Biology, 10(3), 172. https://doi.org/10.3390/biology10030172 |
Abstract: | Evidence suggests that stem cells exert regenerative potential via the release of extracellular vesicles. Mesenchymal stem cell extracellular vesicles (MSCEVs) offer therapeutic benefits for various pathophysiological ailments by restoring tissues. Facts suggest that MSCEV action can be potentiated by modifying the mesenchymal stem cells culturing methodology and bioengineering EVs. Limited clinical trials of MSCEVs have questioned their superiority, culturing quality, production scale-up and isolation, and administration format. Translation of preclinically successful MSCEVs into a clinical platform requires paying attention to several critical matters, such as the production technique, quantification/characterization, pharmacokinetics/targeting/transfer to the target site, and the safety profile. Keeping these issues as a priority, the present review was designed to highlight the challenges in translating preclinical MSCEV research into clinical platforms and provide evidence for the regenerative potential of MSCEVs in various conditions of the liver, kidney, heart, nervous system, bone, muscle, cartilage, and other organs/tissues. |
URI: | https://www.mdpi.com/2079-7737/10/3/172 http://hdl.handle.net/123456789/26082 |
ISSN: | 20797737 |
Appears in Collections: | Journal Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Mesenchymal Stem Cell-Derived Extracellular Vesicles Regenerative Potential and Challenges (1).pdf | 5.87 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.