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http://hdl.handle.net/123456789/29398
Title: | Outer membrane vesicles as biomimetic vaccine carriers against infections and cancers |
Authors: | Nur Najihah Izzati Mat Rani Alzubaidi, Zahraa M Butt, Adeel Masood Nur Dini Fatini Mohammad Faizal Sekar, Mahendran Hanisah Azhari Mohd Cairul Iqbal Mohd Amin (UniKL RCMP) |
Keywords: | Biomimetics Cancer Drug delivery Infections OMVs Vaccines |
Issue Date: | Jul-2022 |
Publisher: | John Wiley and Sons Inc |
Citation: | Nur Njihah Izzati Abdul Rani, Alzubaidi, Z. M., Butt, A. M., Faizal, Nur Dini Fatini Mohammad Faizal, Sekar, M., Hanisah Azhari, & Mohd Cairul Iqbal Mohd Amin (2022). Outer membrane vesicles as biomimetic vaccine carriers against infections and cancers. WIREs Nanomedicine and Nanobiotechnology, 14(4). https://doi.org/10.1002/wnan.1784 |
Abstract: | In the last decade, nanoparticle-based therapeutic modalities have emerged as promising treatment options for cancer and infectious diseases. To improve prognosis, chemotherapeutic and antimicrobial drugs must be delivered selectively to the target sites. Researchers have increasingly focused their efforts on improving drug delivery, with a particular emphasis on cancer and infectious diseases. When drugs are administered systemically, they become diluted and can diffuse to all tissues but only until the immune system intervenes and quickly removes them from circulation. To enhance and prolong the systemic circulation of drugs, nanocarriers have been explored and used; however, nanocarriers have a major drawback in that they can trigger immune responses. Numerous nanocarriers for optimal drug delivery have been developed using innovative and effective biointerface technologies. Autologous cell-derived drug carriers, such as outer membrane vesicles (OMVs), have demonstrated improved bioavailability and reduced toxicity. Thus, this study investigates the use of biomimetic OMVs as biomimetic vaccine carriers against infections and cancers to improve our understanding in the field of nanotechnology. In addition, discussion on the advantages, disadvantages, and future prospects of OMVs will also be explored. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Biology-Inspired Nanomaterials > Protein and Virus-Based Structures. |
URI: | https://ir.unikl.edu.my/jspui/handle/123456789/29398 |
ISSN: | 19395116 |
Appears in Collections: | Journal Articles |
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Outer membrane vesicles as biomimetic vaccine carriers against infections and cancers.pdf | 69.43 kB | Adobe PDF | View/Open |
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