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http://hdl.handle.net/123456789/23342
Title: | Phomopsidione nanoparticles coated contact lenses reduce microbial keratitis causing pathogens |
Authors: | Muhammad Yusoff Bin Sahadan Woei Yenn Tong Wen Nee Tan Chean Ring Leong Mohamad Najib Bin Misri Murphy Chan See Yuan Cheng Shahrulzaman Shaharuddin |
Keywords: | Contact lens Microbial keratitis Phomopsidione Nanoparticles |
Issue Date: | Jan-2019 |
Publisher: | Experimental Eye Research |
Abstract: | Objectives: Pseudomonas aeruginosa is an important aetiological agent causing pneumonia, urinary tract infections and bacteraemia. High antibiotic use in nosocomial settings and for immunocompromised conditions results in increasing multidrug resistance. This study analysed the antimicrobial resistance profile of P. aeruginosa isolates in an HIV setting. Methods: A total of 7386 clinical specimens were collected from HIV patients attending YRG CARE from 2010–2017. P. aeruginosa isolated from clinical specimens were identified conventionally, and antimicrobial susceptibility testing was performed by the Kirby–Bauer disk diffusion method. Results: A total of 260 P. aeruginosa strains were isolated, with 165 P. aeruginosa (63.5%) being isolated from hospitalised patients. A higher incidence of P. aeruginosa infection (25.8%) was observed in 2017, and most of the P. aeruginosa were isolated from sputum specimens (57.3%). A high level of resistance was noted to ceftazidime (49.6%), followed by ticarcillin (41.5%). Imipenem and meropenem resistance was observed in 15.0% and 16.9% of P. aeruginosa isolates, respectively. A high rate of imipenem resistance was noted in 2016 (46.2%) and a high rate of meropenem resistance was noted in 2017 (20.5%). An increasing resistance rate of P. aeruginosa was observed against aztreonam, cefepime, levofloxacin, meropenem, piperacillin, piperacillin/tazobactam, ticarcillin and tobramycin from 2010 to 2017. Conclusion: A constant increase in drug-resistant P. aeruginosa isolates from HIV patients was observed from 2010 to 2017. Findings from this study urge the need for periodical monitoring and surveillance of the P. aeruginosa resistance profile, especially in hospitalised and immunocompromised patients in resource-limited settings |
URI: | 10.1016/j.exer.2018.09.011 http://ir.unikl.edu.my/jspui/handle/123456789/23342 |
ISSN: | 0014-4835 1096-0007 |
Appears in Collections: | Journal Articles |
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File | Description | Size | Format | |
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Phomopsidione nanoparticles coated contact lenses reduce microbial keratitis causing pathogens.pdf | 227.6 kB | Adobe PDF | View/Open |
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