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Recent progress on small molecule TLR4 antagonist against triple-negative breast cancer progression and complications
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| dc.contributor.author | Kathirasan, Darsshen Ramana | |
| dc.contributor.author | Siti Nor ’Izzah Normizan | |
| dc.contributor.author | Nurul Athirah Mohd Salleh | |
| dc.contributor.author | Khor, Poh Yen | |
| dc.contributor.author | (UniKL RCMP) | |
| dc.date.accessioned | 2026-03-09T06:59:20Z | |
| dc.date.available | 2026-03-09T06:59:20Z | |
| dc.date.issued | 2024-12 | |
| dc.identifier.citation | Kathirasan DR, Siti Nor ’Izzah Normizan, Nurul Athirah Mohd Salleh, Khor, PY. Recent progress on small molecule TLR4 antagonist against triple-negative breast cancer progression and complications. Bioorganic & Medicinal Chemistry [Internet]. 2024 Nov 14;116:118000. Available from: https://doi.org/10.1016/j.bmc.2024.118000 | en_US |
| dc.identifier.issn | 09680896 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0968089624004140?via%3Dihub | |
| dc.identifier.uri | https://ir.unikl.edu.my/jspui/handle/ir.unikl.edu.my/33969 | |
| dc.description.abstract | Toll-like receptor 4 (TLR4) plays a vital role in the innate immune response, but its overactivation has been associated with several diseases, such as aggressive progression of triple-negative breast cancer (TNBC). As a result, inhibiting TLR4 has emerged as a potential therapeutic strategy for this challenging breast cancer subtype. This review summarizes recent advancements in the development of small-molecule TLR4 antagonists to suppress TNBC growth, metastasis, and chemotherapy resistance. We also examine their potential in managing cancer-related complications and propose future directions for their application in TNBC therapy. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier Ltd | en_US |
| dc.subject | Angiogenesis | en_US |
| dc.subject | Breast cancer | en_US |
| dc.subject | Complication | en_US |
| dc.subject | Metastases | en_US |
| dc.subject | Myeloid differentiation factor 2 | en_US |
| dc.title | Recent progress on small molecule TLR4 antagonist against triple-negative breast cancer progression and complications | en_US |
| dc.type | Article | en_US |
