Abstract:
The study conducted biosynthesis of copper oxide nanoparticles using an aqueous extract of Aspergillus niger and investigated their potential biomedical applications. The nanoparticles were characterized using various techniques including UV-Vis, SEM, TEM, and EDX, revealing their spherical to crystalline shape with sizes ranging from 21 nm to 48 nm. The nanoparticles demonstrated notable antimicrobial activity against Staphylococcus aureus with a zone of 8 mm and Escherichia coli recorded high synergistic activity with 20.93%, as well as antioxidant properties. Furthermore, selective cytotoxicity towards breast cancer cells was observed with an IC50 of 107.81 ug/ml and an IC50 of 250.93 ug/ml on normal cells, suggesting their potential use as an anticancer agent and for targeted drug delivery.
