Effect of pH and temperature on the activity of glutamate dehydrogenase in Haemonchus contortus.

Abstract

The knowledge of the central aspects of parasite biology is important in developing novel and effective remedies against gastrointestinal nematodes infestations which cause extensive morbidity in humans, livestock and other mammals throughout the world. Since active nitrogen and energy metabolism is required for the free-living larval to survive, the investigations of the metabolic pathways and key enzymes would be an attractive targets for vaccines. Hence, the main aim of this research is to study the kinetic activity of glutamate dehydrogenase (GDH) OF nematode parasite Haemonchus contortus at different pH and temperature.