http://hdl.handle.net/123456789/752 Collection of conferences and journal articles 2026-08-19T14:47:53Z http://hdl.handle.net/ir.unikl.edu.my/34919 Modulation of Sirtuin-1 by Resveratrol as A Potential Therapy in Alleviating Metabolic Syndrome Muhmmad Zulfiqah Sadikan; Afiqq Aiman Abd Ghapor; Nurul Alimah Abdul Nasir; Norhafiza Razali; Nur Hidayah Reshidan; (UniKL RCMP) Objective: This review aims to investigate the therapeutic potential of resveratrol in managing metabolic syndrome, with particular emphasis on its molecular interaction with sirtuin-1 (SIRT1) and its downstream effects on cellular metabolism and signaling pathways. Methods: A comprehensive analysis of preclinical and clinical studies was conducted to evaluate the impact of resveratrol on metabolic syndrome components such as insulin resistance, dyslipidemia, hypertension, and central obesity. Special focus was given to the molecular mechanisms involving SIRT1 activation. The review also examined the involvement of key downstream targets, including peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α), nuclear factor erythroid 2-related factor 2 (Nrf2), and adenosine monophosphate-activated protein kinase (AMPK), which are known to influence energy metabolism, oxidative stress, and inflammation. Results: Resveratrol, a natural polyphenolic compound found in grapes, berries, and red wine, was shown to activate SIRT1, a class III histone deacetylase. SIRT1 activation resulted in improved insulin sensitivity, enhanced mitochondrial biogenesis, and better glucose and lipid metabolism. Furthermore, the downstream activation of PGC-1α, Nrf2, and AMPK contributed to increased energy expenditure, antioxidant defense, and anti- inflammatory responses. Collectively, these effects led to improvements in multiple parameters associated with metabolic syndrome, including reduced body weight, improved lipid profiles, lowered blood pressure, and enhanced glucose regulation. Conclusion: Resveratrol exerts multiple beneficial effects on metabolic syndrome by activating SIRT1 and modulating key metabolic and stress-response pathways. These actions help address the underlying pathophysiological processes of metabolic syndrome, offering promise for its use as a therapeutic agent. Continued research, particularly in human trials, is needed to establish effective dosing and long-term outcomes, but current evidence supports resveratrol’s potential role in metabolic health management 2025-09-01T00:00:00Z http://hdl.handle.net/ir.unikl.edu.my/34916 Development of Pressure Sensor Using Plastic Optical Fiber Thiruvakkarasu, Punithavati; Abd Rahman, Amirul Hakim; Mohammad, Suraya; UniKL BMI This research presents the development of a high-sensitivity pressure sensor using plastic optical fibers (POFs), offering a safe, reliable, and cost-effective alternative to conventional sensors. A POF is modified into a U-shaped sensor by bending method and connected to a white light source and spectrometer set up. The sensor employs a U-shaped design to enhance sensitivity by detecting light intensity changes due to pressure-induced strain. 3cm, 10 cm and 35 cm bending radius are used to determine the best performance for the sensor. The experimental setup includes a controlled weight application system and real-time optical monitoring. Results show that the sensor can detect minute pressure changes with high precision. The best results were obtained for a U radius of 3 cm which yielded a sensitivity of 55 units of intensity / gram. This is 2 times the sensitivity of the 10 cm and more than 4 times the sensitivity of the 35 cm radius sensor. Potential applications include industrial automation, environmental monitoring, and healthcare. This work demonstrates the viability of POF-based sensors in smart sensing networks and contributes to the advancement of next-generation optical sensing technologies. Conference Paper 2026-08-17T00:00:00Z http://hdl.handle.net/ir.unikl.edu.my/34915 Development Of Water PH Sensor Using Plastic Optical Fiber Thiruvakkarasu, Punithavati; Mohd Azmi, Muhammad Hadzim Khuzairy; Mohammad, Suraya; UniKL BMI This project investigates the development and performance of a U-shaped Plastic Optical Fiber (POF) sensor designed for real-time water pH monitoring. The proposed sensor offers a low-cost, durable, and robust solution to overcome the limitations of traditional glass electrode-based pH sensors, which are fragile, require frequent calibration, and are impractical for continuous, real-time monitoring in harsh environments. By utilizing the evanescent field interaction between guided light and a pH-sensitive coating applied to the exposed region of the fiber, the sensor detects pH changes through measurable shifts in light intensity and wavelength. The experimental setup includes a broadband light source, a U-shaped POF sensor, a spectrometer, and AvaSoft 8 software for data collection. Buffer solutions with pH values ranging from 4.0 to 9.18 were used to test the sensor’s response. The results show that the sensor with the 1 cm exposure demonstrated strong sensitivity, repeatability, and a clear linear correlation between pH levels and the spectral response, particularly within the 530–600 nm wavelength range. The findings suggest that the U-shaped sensor can provide an affordable, real-time alternative to existing pH measurement technologies, with potential for future improvements in sensitivity, temperature compensation, and integration with IoT systems for remote monitoring. Conference Paper 2026-08-17T00:00:00Z http://hdl.handle.net/ir.unikl.edu.my/34903 Anthropometric measurements of the external nose among Malay and Chinese: A Cross-sectional study from Sarawak, Malaysia Nwe, Tin Moe; Roy, Bedanta; Yee, Khin Than; Htwe, Than Than; Than, Myo; Lwin, Soe; Yi, Myat San; Latt, Swe Swe; Than, Thida; (UniKL RCMP) Nasal anthropometry is among the best clues to racial origin and sexual determination. The nose's shape and structure differ between genders, races, and ethnicities. The understanding of nasal anthropometry is applied in forensic medicine, nasal reconstruction surgery, and naso-facial dysmorphology identification. This research aimed to investigate the anthropometry of the external noses among Malay and Chinese university students in Sarawak. A total of 80 university students (40 males and 40 females) aged between 18 and 25 participated. The nasal height, length, width, and philtrum length were measured anthropometrically using a slide calliper. Malay males had significantly more nasal width than females (p<0.05). Nasal width, philtrum length, and nasal index were significantly higher in males than female Chinese students (p<0.05). The philtrum length was significantly longer in Chinese students than in Malays (p<0.05). Further study can be done by using a larger sample size to obtain a better representation of the particular ethnicities. In conclusion, sexual dimorphism and ethnic differences can be observed in the anthropometry of the external noses among Malay and Chinese in Sarawak. 2024-03-01T00:00:00Z