http://hdl.handle.net/123456789/756 2026-08-19T15:56:56Z 2026-08-19T15:56:56Z Muhmmad Zulfiqah Sadikan Afiqq Aiman Abd Ghapor Nurul Alimah Abdul Nasir Norhafiza Razali Nur Hidayah Reshidan (UniKL RCMP) http://hdl.handle.net/ir.unikl.edu.my/34919 2026-08-19T01:42:02Z 2025-09-01T00:00:00Z

Modulation of Sirtuin-1 by Resveratrol as A Potential Therapy in Alleviating Metabolic Syndrome Muhmmad Zulfiqah Sadikan; Afiqq Aiman Abd Ghapor; Nurul Alimah Abdul Nasir; Norhafiza Razali; Nur Hidayah Reshidan; (UniKL RCMP) Objective: This review aims to investigate the therapeutic potential of resveratrol in managing metabolic syndrome, with particular emphasis on its molecular interaction with sirtuin-1 (SIRT1) and its downstream effects on cellular metabolism and signaling pathways. Methods: A comprehensive analysis of preclinical and clinical studies was conducted to evaluate the impact of resveratrol on metabolic syndrome components such as insulin resistance, dyslipidemia, hypertension, and central obesity. Special focus was given to the molecular mechanisms involving SIRT1 activation. The review also examined the involvement of key downstream targets, including peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α), nuclear factor erythroid 2-related factor 2 (Nrf2), and adenosine monophosphate-activated protein kinase (AMPK), which are known to influence energy metabolism, oxidative stress, and inflammation. Results: Resveratrol, a natural polyphenolic compound found in grapes, berries, and red wine, was shown to activate SIRT1, a class III histone deacetylase. SIRT1 activation resulted in improved insulin sensitivity, enhanced mitochondrial biogenesis, and better glucose and lipid metabolism. Furthermore, the downstream activation of PGC-1α, Nrf2, and AMPK contributed to increased energy expenditure, antioxidant defense, and anti- inflammatory responses. Collectively, these effects led to improvements in multiple parameters associated with metabolic syndrome, including reduced body weight, improved lipid profiles, lowered blood pressure, and enhanced glucose regulation. Conclusion: Resveratrol exerts multiple beneficial effects on metabolic syndrome by activating SIRT1 and modulating key metabolic and stress-response pathways. These actions help address the underlying pathophysiological processes of metabolic syndrome, offering promise for its use as a therapeutic agent. Continued research, particularly in human trials, is needed to establish effective dosing and long-term outcomes, but current evidence supports resveratrol’s potential role in metabolic health management

2025-09-01T00:00:00Z Thiruvakkarasu, Punithavati Abd Rahman, Amirul Hakim Mohammad, Suraya UniKL BMI http://hdl.handle.net/ir.unikl.edu.my/34916 2026-08-17T04:38:38Z 2026-08-17T00:00:00Z

Development of Pressure Sensor Using Plastic Optical Fiber Thiruvakkarasu, Punithavati; Abd Rahman, Amirul Hakim; Mohammad, Suraya; UniKL BMI This research presents the development of a high-sensitivity pressure sensor using plastic optical fibers (POFs), offering a safe, reliable, and cost-effective alternative to conventional sensors. A POF is modified into a U-shaped sensor by bending method and connected to a white light source and spectrometer set up. The sensor employs a U-shaped design to enhance sensitivity by detecting light intensity changes due to pressure-induced strain. 3cm, 10 cm and 35 cm bending radius are used to determine the best performance for the sensor. The experimental setup includes a controlled weight application system and real-time optical monitoring. Results show that the sensor can detect minute pressure changes with high precision. The best results were obtained for a U radius of 3 cm which yielded a sensitivity of 55 units of intensity / gram. This is 2 times the sensitivity of the 10 cm and more than 4 times the sensitivity of the 35 cm radius sensor. Potential applications include industrial automation, environmental monitoring, and healthcare. This work demonstrates the viability of POF-based sensors in smart sensing networks and contributes to the advancement of next-generation optical sensing technologies. Conference Paper

2026-08-17T00:00:00Z Thiruvakkarasu, Punithavati Mohd Azmi, Muhammad Hadzim Khuzairy Mohammad, Suraya UniKL BMI http://hdl.handle.net/ir.unikl.edu.my/34915 2026-08-17T04:34:09Z 2026-08-17T00:00:00Z

Development Of Water PH Sensor Using Plastic Optical Fiber Thiruvakkarasu, Punithavati; Mohd Azmi, Muhammad Hadzim Khuzairy; Mohammad, Suraya; UniKL BMI This project investigates the development and performance of a U-shaped Plastic Optical Fiber (POF) sensor designed for real-time water pH monitoring. The proposed sensor offers a low-cost, durable, and robust solution to overcome the limitations of traditional glass electrode-based pH sensors, which are fragile, require frequent calibration, and are impractical for continuous, real-time monitoring in harsh environments. By utilizing the evanescent field interaction between guided light and a pH-sensitive coating applied to the exposed region of the fiber, the sensor detects pH changes through measurable shifts in light intensity and wavelength. The experimental setup includes a broadband light source, a U-shaped POF sensor, a spectrometer, and AvaSoft 8 software for data collection. Buffer solutions with pH values ranging from 4.0 to 9.18 were used to test the sensor’s response. The results show that the sensor with the 1 cm exposure demonstrated strong sensitivity, repeatability, and a clear linear correlation between pH levels and the spectral response, particularly within the 530–600 nm wavelength range. The findings suggest that the U-shaped sensor can provide an affordable, real-time alternative to existing pH measurement technologies, with potential for future improvements in sensitivity, temperature compensation, and integration with IoT systems for remote monitoring. Conference Paper

2026-08-17T00:00:00Z Fatinathan, Sharon Siti Nur Hajar Mohamed Anuar Balan, Tavamani Perumal, Vikneswari (UniKL RCMP) http://hdl.handle.net/123456789/33329 2025-11-12T03:09:04Z 2025-07-01T00:00:00Z

PHOTODEGRADATION PATHWAY OF BISPHENOL S BY TITANIUM DIOXIDE UNDER UVA IRRADIATION Fatinathan, Sharon; Siti Nur Hajar Mohamed Anuar; Balan, Tavamani; Perumal, Vikneswari; (UniKL RCMP) Plastic pollution has emerged as a significant global challenge in recent years. It is estimated that 5-10% of the worldwide plastic production ends up in the oceans annually1. In 2020, Malaysia’s plastic consumption amounted to 148 thousand metric tons, with an annual per capita of 16.78 kg2. The “Malaysia Roadmap Towards Zero Single- Use Plastics 2018-2030” was introduced as a three-phase national plan to eliminate single-use plastics3. However, existing plastic waste can snowball into an environmental crisis, as plastic and microplastic waste release various additives during fragmentation. Among these additives, Bisphenol S (BPS) has been identified as an emerging pollutant with the potential to adversely affect humans and animals. Therefore, the removal of this analog from wastewater is essential. This study evaluated the effectiveness of titanium dioxide (TiO2) in photodegrading BPS in an aqueous solution under UVA light while elucidating the photodegradation pathways. Key photodegradation parameters, including the initial pH of the solution, photocatalyst dosage, and illumination period, were optimized. UV-visible spectrophotometer results showed that at an initial concentration of 5 mg/mL, complete photodegradation of BPS occurred within 180 minutes under UVA exposure. Kinetic study showed that the photodegradation process followed the Langmuir-Hinshelwood kinetic model, with a rate constant of 0.0133 min-1. High-performance liquid chromatography (HPLC) analysis identified a single intermediate persisting in the solution after 180 minutes of photodegradation. However, liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis detected four distinct photodegradation peaks and elucidated their formation pathways, revealing a complex degradation pathway. Overall, this study provides valuable insights into the photocatalytic degradation of BPS using TiO2 under UVA irradiation. HPLC and LC-MS/MS analyses confirmed that while BPS undergoes significant degradation under UVA light in the presence of TiO2, its degradation products persist as intermediate in the solution.

2025-07-01T00:00:00Z