http://hdl.handle.net/123456789/752 Collection of conferences and journal articles Tue, 28 Apr 2026 09:43:30 GMT 2026-04-28T09:43:30Z http://hdl.handle.net/ir.unikl.edu.my/34379 Title: Effect of Substituting Coconut Milk with Palm Milk on Shelf Life, Physicochemical and Sensory Properties of Nasi Dagang Authors: Nur Afiqah Zulkifli; Azizah Othman; Seow, Lay Jing; Seow, Eng Keng; (UniKL RCMP) Abstract: A popular Malaysian dish called Nasi Dagang (ND), which originated in Terengganu, consists of steamed rice in coconut milk (CM), fish curry, and additional ingredients such as pickled cucumber and carrots. However, CM with high saturated fat content is always associated with many diseases due to the increased amount of high-density lipoprotein cholesterol. Thus, palm milk (PM) at various concentrations (ND0 with 100% CM, ND1 substituted with 25% PM, ND2 substituted with 50% PM, ND3 substituted with 75% PM and ND4 substituted with 100% PM) were investigated in the present study to examine its effect on the physicochemical and sensory characteristics of ND. Substitution of PM in ND demonstrated an apparent effect on its nutritional value, shelf life, and quality, as evidenced by a greater calcium (4.51 ppm), carbohydrates (16.51%), and lesser fat (5.93%) contents in ND4 than that of ND0. This study discovered that although ND with PM substitution took a longer time to retrograde and turn rancid, the rising moisture content fostered the growth of microorganisms. According to this study, ND prepared with PM has a softer texture since it contains less amylose content (0.37%). Next, sensory acceptability analysis demonstrated that ND1 obtained a higher score than other ND for all aspects, including overall acceptance (7.24). The results showed that substitution of PM in ND had a strong influence on its nutritional value, shelf life, and sensory acceptability. Hence, it can be concluded that PM has a potential to replace CM in ND with certain amount of concentration. Mon, 01 Jul 2024 00:00:00 GMT http://hdl.handle.net/ir.unikl.edu.my/34379 2024-07-01T00:00:00Z http://hdl.handle.net/ir.unikl.edu.my/34371 Title: Comparing Intraperitoneal Adhesion by various Lipid compounds in a Rat Model Authors: Bilal, Hakim Gharib; Muniandy, Subramaniam; Sekar, Mahendran; Khoon, Wong Seak; Firdous, Jannathul; Sugathan, Sandheep; (UniKL RCMP) Abstract: Peritoneal adhesion is a common post-surgical complication, and various methods have been investigated in order to reduce its occurrence. Aim of this study was to explore some of the locally available substances as possible anti peritoneal adhesion agents using mouse model. A total of 32 male Sprague Dawley rats were randomly devided into five groups (control group, auto-cross-linked polysaccharide hyaluronan-based gel rice bran oil, sea cucumber water and fish oil) and the tested agents were introduced into the peritoneum, following laparotomy and the creation of defect was made on left paracolic gutter to facilitate adhesion formation. Fourteen days later the rats were re-operated and the grades of adhesions were recorded. Least adhesion score was noted in group treated with sea cucumber and the test groups treated with rice bran oil and fish oil had the worst adhesion score when compared to the control. Sea cucumber was observed to have the least adhesion score, which could be attributed to its strong healing properties. Rice bran oil and fish oil were found to have the worst adhesion score, indicating that they may have potential to induce adhesion when applied externally. This study provides insight into the various methods that can be used to reduce the formation of peritoneal adhesions. The use of these substances as anti-adhesion agents presents an innovative perspective in the ongoing efforts to mitigate post-surgical complications. Sat, 01 Jun 2024 00:00:00 GMT http://hdl.handle.net/ir.unikl.edu.my/34371 2024-06-01T00:00:00Z http://hdl.handle.net/ir.unikl.edu.my/34362 Title: Biogenic Silver Nanoparticles Combined with L-Arginine Using Escherichia coli and their Antibacterial and Cytotoxic Activities via ROS Production against A-549 Cells Authors: Khairunnisa Imanina M. Nazaruddin; Majeed, Shahnaz; Danish, Mohammed; Mohamad Nasir Mohamad Ibrahim; Sisinthy, Sreenivas Patro; Ansari, Mohammed Tahir; Muthukumarasamy, Ravindran; Alalawi, Ali Mohammed; Kenawy, El-Refaie; Alkahtani, Saad; Al-Zharani, Mohammed; Aljarba, Nada H.; Hasnain, Md Saquib; (UniKL RCMP) Abstract: Background: Silver and its nanoparticles have gained attention owing to their unique physicochemical properties which contribute to their antimicrobial and anticancer properties. The primary focus of this study was the synthesis of silver nanoparticles (AgNPs) using the cell filtrate of Escherichia coli (E. coli) American Type Culture Collection (ATCC) 8739. Methods: Silver nanoparticles were synthesized using E. coli and coated with non-toxic, naturally occurring L-arginine. L-arginine-coated AgNPs (L-AgNPs) were tested for purity, elemental composition, morphology, topology, and stability. Subsequently, they were tested for their antibacterial, apoptotic, reactive oxygen species (ROS), and cytotoxic effects on A549 lung cancer cells using the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results: The study revealed the formation of well-defined nanoparticles with a spherical shape, falling within the size range of 8.8 nm to 44.6 nm. The L-AgNPs exhibited significant antibacterial characteristics, with the largest zone of inhibition observed against Salmonella spp. (18.7 ± 0.9 mm) and the smallest against Bacillus cereus (8.7 ± 0.9 mm). The half maximal inhibitory concentration (IC50) value of L-AgNPs against A549 lung cancer cells was 58.67 μg/mL, while against 3T3-L1 cells, it was measured as 98.03 μg/mL via MTT assay. L-AgNPs induced apoptosis, as confirmed by morphological alterations in the cells, membrane blebbing, and chromatin condensation. These nanoparticles also triggered the production of reactive oxygen species (ROS) due to cellular oxidative stress, as indicated by the increased levels of dichlorodihydrofluorescein (DCF). Conclusion: This research demonstrates the potential application of these L-AgNPs in the biotechnology and pharmaceutical industries for their antibacterial and anticancer properties. Mon, 01 Jul 2024 00:00:00 GMT http://hdl.handle.net/ir.unikl.edu.my/34362 2024-07-01T00:00:00Z http://hdl.handle.net/ir.unikl.edu.my/34287 Title: The effect of Zn-Rich Sambiloto (Andrographis paniculata) Simplicia Powder Diet to SGOT, SGPT and SOD of Stapylococcus aureus induced Wistar Authors: Chean Ring Leong; (UNIKL MICET) Abstract: One source of natural antioxidants considered safer is the bitter plant, which contains many phenolics and flavonoids and high levels of chlorophyll, so it has the potential to act as an immunomodulator. However, the drying process of bitter leaves can reduce chlorophyll levels. This study aims to evaluate the effect of metallochlorophyll formation on the chemical properties of bitter powder, antioxidant activity, and the immunomodulatory effects of Zn-rich bitter powder in vivo. The materials of this study were bitter powder (SP) and SP powder with metallochlorophyll treatment (SZP). Twenty five male Wistar rats were divided into five groups: G1: normal, G2: negative control, G3: commercial immune-boosting supplement intake (SC), G4: SP intake, and G5: SZP intake. Group G1-5 was fed a standard feed of 20 g/day, and group G2-5 was injected with Staphylococcus aureus at a dose of 0.1 ml/head (108 CFU) intraperitoneally. The results showed that forming metallochlorophyll complexes in sambiloto simplicia will increase total chlorophyll and Zn contents and its antioxidant activity compared to natural sambiloto simplicia powder. Intake of Zn-rich sambiloto simplicia powder was able to significantly reduce SGPT, SGOT levels, and increase SOD compared to intake of original sambiloto simplicia powder. Description: This article is index by Scopus Tue, 21 Apr 2026 00:00:00 GMT http://hdl.handle.net/ir.unikl.edu.my/34287 2026-04-21T00:00:00Z