http://hdl.handle.net/123456789/755 2026-06-10T00:57:38Z http://hdl.handle.net/ir.unikl.edu.my/34666 Title: Estimation of Heritability and Genetic Correlation of Quantitative Traits as a Basis for Selection Program of Indonesian Native Chickens Authors: Suyatno, Suyatno; Sujono, Sujono; Winaya, Aris; Zalizar, Lili; Jaganathan, Ravindran; (UniKL RCMP) Abstract: Native chicken is a potential genetic source to produce new superior and productive strains. The genetic parameter information is needed as basis data for the selection program to improve the genetic quality of native chickens. This study aimed to estimate the heritability and genetic correlation of quantitative traits in local Indonesian chickens. The material used is the offspring from outbreeding, crossbreeding, and reciprocal crosses of four native chicken lines: White, Lurik, Wareng, and Ranupane. The traits observed were Body Weight (BW), Body Height (BH), Body Length (BL), Body Circumference (BC), Wing Length (WL), Beak Length (BeL), Head Circumference (HC), Thigh-Shank Length (TSL), and Thigh Circumference (TC). The ANOVA and ANCOVA were used to estimate heritability and genetic correlation based on the mating lines of each cage/pen. The mating line significantly affected all the measured traits (P < 0.05). The highest heritability was obtained for BW (h2 = 0.25, moderate category). A positive genetic correlation was found between BW and all other traits except for BeL and HC. In conclusion, body weight can be considered for early selection because it has the highest heritability and positive genetic correlation with other traits related to body size. 2024-05-01T00:00:00Z http://hdl.handle.net/ir.unikl.edu.my/34665 Title: Aspartame Causes Developmental Defects and Teratogenicity in Zebra Fish Embryo: Role of Impaired SIRT1/FOXO3a Axis in Neuron Cells Authors: Pandaram, Athiram; Paul, Jeyakumari; Wankhar, Wankupar; Thakur, Abhimanyu; Verma, Sakshi; Vasudevan, Karthick; Wankhar, Dapkupar; Kammala, Ananth Kumar; Sharma, Priyanshu; Jaganathan, Ravindran; Iyaswamy, Ashok; Rajan, Ravindran; (UniKL RCMP) Abstract: Aspartame, a widely used artificial sweetener, is present in many food products and beverages worldwide. It has been linked to potential neurotoxicity and developmental defects. However, its teratogenic effect on embryonic development and the underlying potential mechanisms need to be elucidated. We investigated the concentration- and time-dependent effects of aspartame on zebrafish development and teratogenicity. We focused on the role of sirtuin 1 (SIRT1) and Forkhead-box transcription factor (FOXO), two proteins that play key roles in neurodevelopment. It was found that aspartame exposure reduced the formation of larvae and the development of cartilage in zebrafish. It also delayed post-fertilization development by altering the head length and locomotor behavior of zebrafish. RNA-sequencing-based DEG analysis showed that SIRT1 and FOXO3a are involved in neurodevelopment. In silico and in vitro analyses showed that aspartame could target and reduce the expression of SIRT1 and FOXO3a proteins in neuron cells. Additionally, aspartame triggered the reduction of autophagy flux by inhibiting the nuclear translocation of SIRT1 in neuronal cells. The findings suggest that aspartame can cause developmental defects and teratogenicity in zebrafish embryos and reduce autophagy by impairing the SIRT1/FOXO3a axis in neuron cells. 2024-03-01T00:00:00Z http://hdl.handle.net/ir.unikl.edu.my/34664 Title: Arthroscopic-Assisted Distal Radius Fracture Fixation Using the NanoScope System Authors: Choke, Abby; Chung, Sin Fah; Chung, Sze Ryn; (UniKL RCMP) Abstract: Intra-articular distal radius fractures with significant articular step-off and gapping are associated with high risk of developing symptomatic arthritis and poor functional outcome. The use of arthroscopy for distal radius fixation had been well published in the literature. It allows the surgeon to fine-tune intra-articular fragments to achieve articular congruency, address ligamentous disruption, and check for screw penetration within the joint. Various techniques have been reported, including volar locking plate presetting to aid in arthroscopic reduction. Here, we demonstrate our arthroscopic-assisted distal radius fixation technique using a 1.9-mm miniature scope NanoScope (Arthrex, Naples, FL). 2024-09-01T00:00:00Z http://hdl.handle.net/ir.unikl.edu.my/34660 Title: Occult hepatitis B virus infection and current perspectives on global WHO 2030 eradication Authors: Saravanan, Shanmugam; Shankar, Esaki M; Vignesh, Ramachandran; Ganesh, Pitchaipillai Sankar; Sankar, Sathish; Velu, Vijayakumar; Smith, Davey M; Balakrishnan, Pachamuthu; Viswanathan, Dhivya; Govindasamy, Rajakumar; Venkateswaran, Arcot R; (UniKL RCMP) Abstract: The current World Health Organization (WHO) Hepatitis Elimination Strategy suffers from lack of a target for diagnosing or expunging occult HBV infection. A sizable segment of the global population has an undetected HBV infection, particularly the high-risk populations and those residing in countries like India with intermediate endemicity. There is growing proof that people with hidden HBV infection can infect others, and that these infections are linked to serious chronic hepatic complications, especially hepatocellular carcinoma. Given the current diagnostic infrastructure in low-resource settings, the WHO 2030 objective of obliterating hepatitis B appears to be undeniably challenging to accomplish. Given the molecular basis of occult HBV infection strongly linked to intrahepatic persistence, patients may inexplicably harbour HBV genomes for a prolonged duration without displaying any pronounced clinical or biochemical signs of liver disease, and present histological signs of moderate degree necro-inflammation, diffuse fibrosis, and hence the international strategy to eradicate viral hepatitis warrants inclusion of occult HBV infection. 2024-07-01T00:00:00Z