DSpace Collection:http://hdl.handle.net/123456789/7552023-12-14T23:45:02Z2023-12-14T23:45:02ZAdvances in Polyhydroxyalkanoate Nanocarriers for Effective Drug Delivery: An Overview and ChallengesPrakash, PriyankaLee, Wing-HinLoo, Ching-YeeWong, Hau Seung JeremyParumasivam, Thaigarajan(UniKL RCMP)http://hdl.handle.net/123456789/291812023-12-07T07:30:32Z2022-01-01T00:00:00ZTitle: Advances in Polyhydroxyalkanoate Nanocarriers for Effective Drug Delivery: An Overview and Challenges
Authors: Prakash, Priyanka; Lee, Wing-Hin; Loo, Ching-Yee; Wong, Hau Seung Jeremy; Parumasivam, Thaigarajan; (UniKL RCMP)
Abstract: Polyhydroxyalkanoates (PHAs) are natural polymers produced under specific conditions by certain organisms, primarily bacteria, as a source of energy. These up-and-coming bioplastics are an undeniable asset in enhancing the effectiveness of drug delivery systems, which demand characteristics like non-immunogenicity, a sustained and controlled drug release, targeted delivery, as well as a high drug loading capacity. Given their biocompatibility, biodegradability, modifiability, and compatibility with hydrophobic drugs, PHAs often provide a superior alternative to free drug therapy or treatments using other polymeric nanocarriers. The many formulation methods of existing PHA nanocarriers, such as emulsion solvent evaporation, nanoprecipitation, dialysis, and in situ polymerization, are explained in this review. Due to their flexibility that allows for a vessel tailormade to its intended application, PHA nanocarriers have found their place in diverse therapy options like anticancer and anti-infective treatments, which are among the applications of PHA nanocarriers discussed in this article. Despite their many positive attributes, the advancement of PHA nanocarriers to clinical trials of drug delivery applications has been stunted due to the polymers’ natural hydrophobicity, controversial production materials, and high production costs, among others. These challenges are explored in this review, alongside their existing solutions and alternatives.2022-01-01T00:00:00ZDENV-Mimetic Polymersome Nanoparticles Bearing Multi-Epitope Lipopeptides Antigen as the Next-Generation Dengue VaccineNur Adilah Abdul RahmanAbdin Shakirin Mohamad NorpiMuhammad Luqman NordinMohd Cairul Iqbal Mohd AminAbdullah Al-Hadi Ahmad FuaadNor Azila Muhammad AzamiMarasini, NirmalFazren Azmi(UniKL RCMP)http://hdl.handle.net/123456789/291762023-12-06T09:26:42Z2022-01-01T00:00:00ZTitle: DENV-Mimetic Polymersome Nanoparticles Bearing Multi-Epitope Lipopeptides Antigen as the Next-Generation Dengue Vaccine
Authors: Nur Adilah Abdul Rahman; Abdin Shakirin Mohamad Norpi; Muhammad Luqman Nordin; Mohd Cairul Iqbal Mohd Amin; Abdullah Al-Hadi Ahmad Fuaad; Nor Azila Muhammad Azami; Marasini, Nirmal; Fazren Azmi; (UniKL RCMP)
Abstract: Dengue remains a severe threat to public health. The safety and efficacy of the licensed dengue vaccine is not clinically satisfactory, which necessitate the need of new approach in designing an effective dengue vaccine without eliciting adverse reaction. Herein, we have designed a lipidated multi-epitope peptide vaccine (LipoDV) that can elicit highly targeted humoral and cell-mediated immune responses. To improve its immunogenicity, LipoDV was presented on the surface of MPLA-functionalized polymersome nanoparticles (PNs-LipoDV-MPLA). The as-constructed vaccine delivery platform resembles the structural morphology of DENV owing to its spherical nanoscale particle size and surface immunostimulatory properties given by LipoDV and MPLA that emulating the functional role of DENV E and prM/M proteins respectively. A proof-of-concept study demonstrated that BALB/c mice immunized with PNs-LipoDV-MPLA induced a stronger antigen-specific antibody response with an enhanced cell-mediated immunity as characterized by the elevated IFN-γ secretion in comparison to other tested vaccine candidates which possess a lesser structural trait of DENV. The DENV-mimicking nanoparticles vaccine exhibited negligible toxicity as analyzed by hemolytic test, MTT assay, histopathological examination and abnormal toxicity test on immunized mice. Collectively, our study provides a strong foundation in designing an effective peptide-based vaccine delivery platform against DENV infection.2022-01-01T00:00:00ZPromising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of ActionNurul Amirah Mohd ZaidSekar, MahendranBonam, Srinivasa ReddyGan, Siew HuaLum, Pei TengBegum, YasminNur Najihah Izzati Mat RaniVaijanathappa, JaishreeWu, Yuan SengSubramaniyan, VetriselvanFuloria, Neeraj KumarFuloria, Shivkanya(UniKL RCMP)http://hdl.handle.net/123456789/291752023-12-06T09:11:14Z2022-01-01T00:00:00ZTitle: Promising Natural Products in New Drug Design, Development, and Therapy for Skin Disorders: An Overview of Scientific Evidence and Understanding Their Mechanism of Action
Authors: Nurul Amirah Mohd Zaid; Sekar, Mahendran; Bonam, Srinivasa Reddy; Gan, Siew Hua; Lum, Pei Teng; Begum, Yasmin; Nur Najihah Izzati Mat Rani; Vaijanathappa, Jaishree; Wu, Yuan Seng; Subramaniyan, Vetriselvan; Fuloria, Neeraj Kumar; Fuloria, Shivkanya; (UniKL RCMP)
Abstract: The skin is the largest organ in the human body, composed of the epidermis and the dermis. It provides protection and acts as a barrier against external menaces like allergens, chemicals, systemic toxicity, and infectious organisms. Skin disorders like cancer, dermatitis, psoriasis, wounds, skin aging, acne, and skin infection occur frequently and can impact human life. According to a growing body of evidence, several studies have reported that natural products have the potential for treating skin disorders. Building on this informa-tion, this review provides brief information about the action of the most important in vitro and in vivo research on the use of ten selected natural products in inflammatory, neoplastic, and infectious skin disorders and their mechanisms that have been reported to date. The related studies and articles were searched from several databases, including PubMed, Google, Google Scholar, and ScienceDirect. Ten natural products that have been reported widely on skin disorders were reviewed in this study, with most showing anti-inflammatory, antioxidant, anti-microbial, and anti-cancer effects as the main therapeutic actions. Overall, most of the natural products reported in this review can reduce and suppress inflammatory markers, like tumor necrosis factor-alpha (TNF-α), scavenge reactive oxygen species (ROS), induce cancer cell death through apoptosis, and prevent bacteria, fungal, and virus infections indicating their potentials. This review also highlighted the challenges and opportunities of natural products in transdermal/topical delivery systems and their safety considerations for skin disorders. Our findings indicated that natural products might be a low-cost, well-tolerated, and safe treatment for skin diseases. However, a larger number of clinical trials are required to validate these findings. Natural products in combination with modern drugs, as well as the development of novel delivery mechanisms, represent a very promising area for future drug discovery of these natural leads against skin disorders.2022-01-01T00:00:00ZA review on epidermal growth factor receptor's role in breast and non-small cell lung cancerSubramaniyan, VetriselvanFuloria, ShivkanyaGupta, GauravDarnal, Hari KumarSekar, MahendranV. Sathasivam, KathiresanSudhakar, KalvatalaAlharbi, Khalid SaadAl-Malki, Waleed HassanAfzal, ObaidKazmi, ImranAl-Abbasi, Fahad A.Altamimi, Abdulmalik Saleh AlfawazFuloria, Neeraj Kumar(UniKL RCMP)http://hdl.handle.net/123456789/291742023-12-06T08:56:48Z2022-01-01T00:00:00ZTitle: A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer
Authors: Subramaniyan, Vetriselvan; Fuloria, Shivkanya; Gupta, Gaurav; Darnal, Hari Kumar; Sekar, Mahendran; V. Sathasivam, Kathiresan; Sudhakar, Kalvatala; Alharbi, Khalid Saad; Al-Malki, Waleed Hassan; Afzal, Obaid; Kazmi, Imran; Al-Abbasi, Fahad A.; Altamimi, Abdulmalik Saleh Alfawaz; Fuloria, Neeraj Kumar; (UniKL RCMP)
Abstract: Epithelial growth factor receptor (EGFR) is a cell surface transmembrane receptor that mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell and thereby alter the function of nucleus. This leads to the generation of various protein products to up or downregulate the cellular function. It is encoded by cell erythroblastosis virus oncogene B1, so called C-erb B1/ERBB2/HER-2 gene that acts as a proto-oncogene. It belongs to the HER-2 receptor-family in breast cancer and responds best with anti-Herceptin therapy (anti-tyrosine kinase monoclonal antibody). HER-2 positive breast cancer patient exhibits worse prognosis without Herceptin therapy. Similar incidence and prognosis are reported in other epithelial neoplasms like EGFR + lung non-small cell carcinoma and glioblastoma (grade IV brain glial tumor). Present study highlights the role and connectivity of EGF with various cancers via signaling pathways, cell surface receptors mechanism, macromolecules, mitochondrial genes and neoplasm. Present study describes the EGFR associated gene expression profiling (in breast cancer and NSCLC), relation between mitrochondrial genes and carcinoma, and several in vitro and in vivo models to screen the synergistic effect of various combination treatments. According to this study, although clinical studies including targeted treatments, immunotherapies, radiotherapy, TKi-EGFR combined targeted therapy have been carried out to investigate the synergism of combination therapy; however still there is a gap to apply the scenarios of experimental and clinical studies for further developments. This review will give an idea about the transition from experimental to most advanced clinical studies with different combination drug strategies to treat cancer.2022-01-01T00:00:00Z